| abstract |
The invention relates to the field of compound synthesis, and mainly relates to a class of difluoro methylene piperidine carboxamide derivatives (I), a pharmaceutical composition containing same, and a preparation method and use thereof, wherein the definition of R 1 is shown in the description. Pharmacodynamic tests prove that the compound of the invention has a CCR5 antagonistic action, can be used as an inhibitor for HIV virus entry, and can also be developed into an anti-AIDS medicine. |