http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016075477-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd344c9d05c6736d44c038fd089d9047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c730fb07e94a47a54fa9d87f2d56b82 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2015-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be87196373133b0765ace5af35630c7e |
| publicationDate | 2016-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2016075477-A1 |
| titleOfInvention | Process for the purification of the axl tyrosine receptor kinase inhibitor "r428" |
| abstract | A process for purifying 1-(6,7-dihydro-5 H -benzo[6,7]cyclohepta[1,2-c]pyridazine-3-yl)- N n 3 - (7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5 H -benzo[7]annulene-2-yl)-1 H -1,2,4-triazole-3,5- diamine free base is described, the process comprising a) dissolving a quantity of crude 1-(6,7-dihydro-5 H - benzo[6,7]cyclohepta[1,2-c]pyridazine-3-yl)- N n 3 -(7-(pyrrolidin-1-yl)-6,7,8,9- tetrahydro-5 H -benzo[7]annulene-2-yl)-1 H -1,2,4-triazole-3,5-diamine in a mixed solvent of C 1-5 alcohol and water, together with an acid, and b) increasing the pH of the solution resulting from (a) until 1-(6,7-dihydro-5 H -benzo[6,7]cyclohepta[1,2-c]pyridazine-3-yl)- N n 3 -(7-(pyrrolidin-1-yl)-6,7,8,9- tetrahydro-5 H -benzo[7]annulene-2-yl)-1 H -1,2,4-triazole-3,5-diamine free base is precipitated from the alcohol-water mixed solvent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9994553-B2 |
| priorityDate | 2014-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.