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filingDate 2015-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acb1a3da61f04a260acf9739d30628cb
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publicationDate 2016-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016066328-A1
titleOfInvention Biologically active biomimetic tissue-engineered blood vessels for small diameter applications
abstract This invention concerns a composition consisting of biologically inert anionic polymers (alginate and carboxymethyl chitosan) and biologically active polymers (polyanionic inorganic polyphosphate and/or silica, and polycations, such as polyamines and/or polymers of basic amino acids, and/or synthetic oligo- or polypeptides containing the RGD motif, either alone or in combination) as a well as cross-linking calcium ions, that can be used for the fabrication of biologically active artificial blood vessels in particular in the small-diameter range. In addition, this invention concerns a device for the formation (pressing out) of the artificial blood vessels with the inventive composition. The novel blood vessels can be used as prosthetic vascular grafts in the surgical treatment of cardiovascular patients like patients requiring coronary and peripheral vessel reconstruction or aneurysm repair.
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