| abstract |
An artificial construct for tissue repair and regeneration comprising multiple collagen sheets laminated into a stack, the construct having multiple pores formed therein and an alginate incorporated into both sides of the construct. The collagen-alginate construct can provide improved host integration upon implantation. The alginate may include cells (e.g., mesenchymal stem cells), growth factors, and cytokines that can enhance healing and promote new tissue formation. Mechanical properties of the construct can be adjusted for different tissue repair applications by varying thickness and number of collagen sheets, pore sizes, patterns, and number, and other parameters. The construct can be configured to have a desired flexibility while maintaining appropriate strength and structural integrity. |