| abstract |
Provided in the present invention are a YAP protein inhibiting polypeptide and a use thereof. In particular, the present invention obtains a key binding site of a YAP protein and TEAD, screens out a polypeptide with the best YAP inhibitory activity and modifies the polypeptide, for example by adding a disulfide linkage, replacing an amino acid, deleting and/or adding (for example, adding a cell-penetrating fragment), and finally screens, verifies and obtains a series of polypeptides with a YAP protein activity inhibiting effect and good stability. Experiments demonstrate that the polypeptide of the present invention can effectively inhibit the binding activity between YAP protein and TEAD, thus providing a good therapeutic effect on digestive tract tumours (especially liver cancer). |