| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb9c6b40161bafe7bd55f0b4defcea04 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate |
2015-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdac95ec961087de40d71e3e0fe68474
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a9d49b919e77cdc7b88bf5aab12f1eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3daef47b9be14ffa2192dc594cf0e1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0098e766898afd8d064a5727f4229d8a |
| publicationDate |
2016-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016057903-A1 |
| titleOfInvention |
Methods for discovering therapeutics that alter the stability of target proteins |
| abstract |
The present application relates, in some aspects, to screening methods to identify test compounds that stabilize or destabilize a protein of interest. The present application is based, in some aspects, on the development of a plasmid that can be used to efficiently monitor the stabilities of thousands of proteins after specific perturbations. The plasmid allows for the co-expression of two reporter proteins, each of which is placed under the control of an IRES. In this way both reporters are transcribed together (i.e. are encoded by the same mRNA) and both are translated using an IRES. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019013215-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018053006-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11340216-B2 |
| priorityDate |
2014-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |