abstract |
Provided are a conotoxin polypeptide κ-CPTx-bt104, a method for preparation thereof, and an application thereof. The conotoxin polypeptide consists of 11 amino acids, has a molecular weight of 1313.47 daltons, and has the full sequence SLCCPEDRWCC. The conotoxin polypeptide has a potassium ion channel current-suppression effect and an analgesic effect, and may be used for drug development and clinical applications to treat pain, epilepsy, stroke, convulsions, muscle relaxation, Parkinson's disease, Alzheimer's disease, depression, addiction, cardiovascular disease, cancer, inflammation, and other diseases. |