| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec5b8c0fc1f827c1360a8f5ea5652225 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0006
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01001 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y401-01001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-88 |
| filingDate |
2015-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d0b8df3f14f55bbd3ce2d62f03c253b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b329a18596a0b560fab5b8c7fd468628
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16a5d8e7e5f4d2d981f4ed1dbc0afcc4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af48618a72f7de4df984a9c49a8e1a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3994c75f6d9295b004bda66f429610 |
| publicationDate |
2016-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016041533-A1 |
| titleOfInvention |
Lyase and lyase-encoding dna, vectors containing the dna, and method for the asymmetric synthesis of (s)-phenylacetylcarbinol |
| abstract |
The invention relates to a lyase and a lyase-encoding DNA, to vectors containing the DNA and to a method for the asymmetric synthesis of (S)-phenylacetylcarbinol. According to the invention, a lyase is provided, in which tryptophan is replaced with an amino acid at position 543 in protein ApPDC-E469G, said protein being modified with respect to the wild type of Aceobacter pasteurianus, or in which it is less space-filling than tryptophan. According to the invention, deoxyribonucleic acids are furthermore provided, which encode the lyase. (S)-phenylacetylcarbinol can be produced with the lyase according to the invention from the educts benzaldehyde and pyruvate or acetaldehyde with an enantiomeric excess of at least 94 %. |
| priorityDate |
2014-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |