| abstract |
The present invention pertains to a compound that has an excellent retinoic acid receptor-related orphan receptor γt inhibitory effect, or a pharmaceutically acceptable salt thereof. Provided is a compound represented by general formula (I), or a pharmaceutically acceptable salt thereof. (In the formula, R 1 is a C 1 -C 6 alkyl group, a C 3 -C 6 cycloalkyl group, or a phenyl group. R 2 is a hydrogen atom, a halogen atom, a C 1 -C 6 alkyl group, or the like. R 3 is a hydrogen atom, a C 2 -C 7 carboxyalkyl group, or a hydroxyl group. R 4 is a halogen atom or a C 1 -C 6 alkyl group. R 5 is a hydrogen atom or a C 1 -C 6 alkyl group. R 6 is a hydrogen atom, a halogen atom, or a C 1 -C 6 alkyl group. R 7 is a hydrogen atom, a halogen atom, or the like. R 8 is a hydroxyl group, a C 1 -C 6 alkoxy group, a mono-C 1 -C 6 alkylamino group, or the like. L is a single bond, a methylene group, or an oxygen atom. E is a phenylene group optionally substituted independently with one or two groups selected from halogen atoms, C 1 -C 6 alkyl groups, and C 1 -C 6 alkylsulfonyl groups, or the like. Q 1 is a nitrogen atom or a group represented by the formula =CH—. Q 2 is a nitrogen atom or a group represented by the formula =CH—. The group represented by the formula —U—T— is a group represented by the formula —CH 2 —CH 2 — or the like. Y is a methylene group or an oxygen atom. V is a nitrogen atom or a group represented by the formula =C(R 9 )—. R 9 is a hydrogen atom, a C 1 -C 6 alkyl group, or the like.) |