| abstract |
Cyclohexylethyl substituted diaza- and triaza-tricyclic compounds, such as e.g. 5-(2-(cyclohexyl)ethyl)-5H-imidazo[5,1-a]isoindole, 1-Cyclohexyl-2-[4,6,10-triazatricyclo[6.4.0.0^[2,6]]dodeca-1(8),2,4,9,11-pentaen-7-yl]ethan-1-ol derivatives and 1-Cyclohexyl-2-[4,6,9,11-tetraazatricyclo[6.4.0.0^[2,6]]dodeca-1(8),2,4,9,11-pentaen-7-yl]ethan-1-ol derivatives as indole-amine-2,3-dioxygenase (IDO) antagonists for the treatment of e.g. cancer, proliferative disorder, viral disease, sepsis, pneumonia, bacteremia, trauma, tuberculosis, parasitic disease, neuroinflammation, schizophrenia, depression, neurodegenerative disease and pain. |