| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3a01b371f80b68c61a8cb38928214240 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B2503-42 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-4848
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-063
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y111-01009
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-145
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35e25d0504aa12e163bbf0311e0171f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a9c7589d753bbf3b1ade707ef6fee1d |
| publicationDate |
2016-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016033615-A1 |
| titleOfInvention |
Methods of screening for drugs to prevent noise-induced hearing loss |
| abstract |
The invention relates to methods of identifying a composition useful for the prevention or treatment of noise-induced hearing loss. The method includes exposing a mammalian test subject to a candidate composition and a calibrated sound or noise challenge. Next, a temporary threshold shift (TTS) is monitored in the test subject over a period of time. The monitored TTS is compared with a TTS of a control subject exposed to a control composition. The presence or absence is determined by clinically relevant and statistically significant differences between the monitored TTS in the test subject and the TTS of the control subject, and the presence of a statistically significant difference identifies the candidate composition as useful for prevention or treatment of noise-induced hearing loss. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101893604-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170026266-A |
| priorityDate |
2014-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |