http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016030704-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9e89ac93235ae7879eb3264fbd47814f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5053f82a7cd17c60822674b657cfb89e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2015-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2daedcfd4e4d4943a9eb19937315b13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c4fd4218a10f571aea0de59505a6dd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_433703566776c87a9d80b0a2417d4f65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17c6fbd0d93bc47cb72c34b21332ddf8 |
| publicationDate | 2016-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2016030704-A1 |
| titleOfInvention | Solid form of intermediate of ticagrelor |
| abstract | A process for the preparation of a solid form of a compound of formula (VII) (Formula (VII)) comprises coupling(1 R ,2 S )-2-(3,4-difluorophenyl)cyclopropanamine (R)-Mandelic acid of Formula (VI) with (2-[[(3a R ,4 S ,6 R ,6aS)-6-[7-chloro-5-(propylthio)-3 H -1,2,3-triazolo[4,5- d ]pyrimidin-3-yl]-2,2- dimethyltetrahydro-3a H -cyclopenta[d[[1,3]dioxol-4-yl]oxy]-1-ethanol) of formula (V) in the presence of a suitable base and a first a suitable solvent at a suitable temperature to form 2- [[(3aR,4S,6R,6aS)-6-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3- triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]-1- ethanol of formula (VI)I; and isolating the compound of formula (VII) using a second suitable solvent so as to produce the compound of formula (VII) in solid form. A process for preparing Ticagrelor of formula (I) or a salt thereof (Formula (I)) comprises the conversion of a compound of formula (VII) in a solid form either as free base or as an acid addition salts thereof, into a compound of formula (I). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115181101-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108892670-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110467619-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111978305-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111978326-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111978305-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108299441-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105669681-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110684029-A |
| priorityDate | 2014-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.