| abstract |
Novel efficient, time-saving and reliable radiofluorination procedures for the production of 18 F-labelled active esters via nucleophilic substitution of the corresponding onium precursors with 18F- are described. The active ester including [ 18 F]F-Py-TFP and [ 18 F]TFB produced by one of these methods was used to prepare PSMA-specific PET tracers such as [ 18 F]DCFPyL. The key advantages of these inventive methods are efficiency, short time of preparation and excellent amenability to automation. A pharmaceutical composition containing at least one PSMA-specific PET tracers prepared by the inventive method is useful for positron emission tomography (PET) imaging, especially imaging prostate tumor. |