| abstract |
The present invention is directed to pharmaceutical compositions and methods of use. The pharmaceutical compositions comprise a central nervous system (CNS) active agent and pseudoephedrine (PSE), phenylephrine (PHE), or both. In some embodiments, the pharmaceutical compositions further comprise a mechanoreceptor stimulator. The PSE, PHE and the mechanoreceptor stimulator are in an amount sufficient to reduce a side-effect of the CNS active agent. The methods of reducing side-effects of a CNS active agent comprises administering the CNS active agent and administering PSE, PHE, or both to the subject, wherein the administration of the CNS active agent and the PSE and/or PHE is synchronized and there is chronological overlap in physiological activity of the CNS active agent and of PSE and/or PHE. |