http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016026732-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce7c542a5a6dc02c10fc2e0a619c4186 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4458 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate | 2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30f54c18b719b5a1be71bec43c171819 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fecbf93928db31e668d631dd297ff237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4b39e5f95c96b6a8ca574b178a15918 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c889fdeb1e1c8f3ffc3856b6138d91f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e2e82bee6757cd10a166ea8447f6a00 |
| publicationDate | 2016-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2016026732-A1 |
| titleOfInvention | Method and kit for assessment of sodium channel-related anti- or pro-arrhythmic potential of compounds |
| abstract | The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro- arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018056527-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10481148-B2 |
| priorityDate | 2014-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.