| abstract |
Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC® F127, exhibit sustained release of DSP for up to 7 days in vitro . These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization. |