http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016023896-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_869c6166374610f52497f319be29772c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-047 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-405 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate | 2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30f213ef642af68af2a7bf9476e78124 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c097431d265595151f296439f63e471 |
| publicationDate | 2016-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2016023896-A1 |
| titleOfInvention | Enzyme fused to a leader for cyclic peptide display |
| abstract | The invention provides a method of biosynthesis of a cyclic peptide by enzymatically transforming a substrate peptide into the cyclic peptide, wherein the substrate peptide is expressed by a displaying genetic package and the enzyme is an enzyme-leader-fusion protein (ELF) which is a post-translationally modifying enzyme (PTME) that is fused to a cognate PTME-leader peptide, thereby obtaining the displaying genetic package carrying the cyclic peptide; and further provides a library of immobilized cyclic peptides, each with a length of at least 10 amino acids, obtainable by a method wherein a repertoire of variant substrate peptides comprising a randomised sequence is transformed by at least two ELFs which differ in the class of the PTMEs, which library comprises a variety of at least 10 6 library members, which variety comprises at least one of a) a different type of a heteroatom bridge linking amino acid side chains of the substrate peptide thereby forming a loop within the substrate peptide; b) a different loop position; or c) a different number of loops. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018187482-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11021518-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427617-B2 |
| priorityDate | 2014-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 493.