http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016018045-A1

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filingDate 2015-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3441f502086766605aeec8d9d2f227de
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publicationDate 2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016018045-A1
titleOfInvention Pharmaceutical composition containing leuprolide and having both immediate and sustained release properties
abstract The present invention relates to a pharmaceutical composition containing leuprolide acetate and having both immediate and sustained release properties and, more specifically, to a pharmaceutical composition in which, on the basis of the total weight of active ingredients, leuprolide as an immediate release preparation is contained in 0.001 wt% to 25 wt%; and leuprolide contained in microspheres of a sustained release preparation is contained in 75 wt% to 99.999 wt%. The pharmaceutical composition of the present invention is characterized by satisfying both a drug immediate release property so as to realize the prompt exposure to a sufficient amount of drug at the early stage for expression of medicinal effects and a drug sustained release property for four weeks or longer, and the pharmaceutical composition is effective in the prevention and treatment of sex hormone-dependent positive or malignant diseases.
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