| abstract |
The invention relates to a method for diagnosing fibromyalgia using microRNAs. The invention provides a method for molecular diagnosis of fibromyalgia patients, based on analysing the possible alteration of the levels of certain microRNAs in peripheral blood mononuclear cells. The method includes analysing the levels of microRNAs miR-223, miR-451, miR-338, miR-143 and miR-145 and diagnosing fibromyalgia when at least one, or preferably multiple, of said microRNAs has lower levels than a reference value, which is preferably the level of each microRNA in healthy individuals. Three additional microRNAs are also provided — miR-21, miR-1260b and miR-1908 — which can be used as a negative control to confirm the diagnosis. The method enables objective diagnosis of fibromyalgia based on molecular markers which are determined from a sample which is easy to obtain and process, such as blood. |