http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016015172-A1

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publicationDate 2016-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016015172-A1
titleOfInvention Tumor treatment method for blocking tumor vasculature by means of nanomaterial and external radiation source
abstract The present invention discloses a new use for a nanomaterial. The new use is an application in the preparation of a tumor vessel blocker, said nanomaterial having all of the following properties: (1) the surface is hydrophilic; (2) the surface has electronegativity; (3) the size of the nanomaterial is 50-250 nm, and the material is rigid, such that it is not prone to passing through the hole in the wall of a tumor vessel and becoming stuck in said hole; (4) the nanomaterial can absorb external radiation energy, and internally convert same to thermal energy, and accumulate said thermal energy, causing the morphological structure of said nanomaterial to change dramatically. During treatment, the described nanomaterial is injected into a tumor-bearing organism, then radiation is applied to the tumor section, causing the nanomaterial to absorb the radiation energy and its internal temperature to rise rapidly; when the temperature has risen to a certain level, the morphological structure of the nanomaterial changes (explosion or dramatic volume expansion), thereby causing the morphological structure or function of the tumor vascular endothelial cells to change, destroying the tumor vasculature.
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