| abstract |
Provided are an amyloid fibril formation inhibitor and a therapeutic or prophylactic drug for neurodegenerative diseases, said inhibitor and drug comprising a compound represented by general formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same.nIn general formula (I): X represents an oxygen atom, etc.; Y represents -CH 2 -, etc.; Z represents -(CH 2 ) l -C(O)-(CH 2 ) m -NH-(CH 2 ) n -, etc.; Ar represents an aryl group or a heteroaryl group; R 1 and R 2 independently represent a hydrogen atom, an alkyl group, an alkoxyalkyl group, etc., or R 1 and R 2 may together form a ring; R 3 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an alkoxy group, etc.; and R 4 represents a hydrogen atom, etc. |