| abstract |
The present invention provides novel amino lipids and a method for synthesizing these compounds. According to the invention, the amino lipids have a structure of the following formula (I) wherein Z is either hydrogen or -X 1 R 1 , R 1 and R 2 are the same or different and independently C 6 -C 24 alkyl, C 6 -C 24 alkenyl, C 6 -C 24 alkynyl, or C 6 -C 24 acyl, which can be optionally substituted with a C 1 -C 6 hydrocarbyl group, X 1 and X 2 are the same or different, either S or S=O or S(=O) 2 , Y is either (II) or heterocycles of the formula (III) or (IV) wherein k and I are integers from 0 to 2, R 3 and R 4 are either the same or different and independently C 1 -C 12 alkyl, C 1 -C 12 alkenyl, or C 1 -C 12 alkynyl, wherein alkyl, alkenyl or alkynyl may be optionally substituted with a C 1 -C 6 hydrocarbyl group, or R 3 and R 4 optionally join to form, together with the nitrogen atom to which they are bound, an optionally substituted N-heterocyclic ring of 3 to 10 atoms comprising 1 to 7 nitrogen atoms, or R 3 and R 4 are the same or different alkyl amines; R 5 and R 6 are either absent or is hydrogen or C 1 -C 12 alkyl to provide a quaternary amine, R 7 is either hydrogen or C 1 -C 12 alkyl, m is an integer from 1 to 12, n is an integer from 1 to 12, and p is an integer from 1 to 3, wherein preferably Y = N for p = 2 or 3. |