| abstract |
The present invention relates to a method for preparing an Eribulin intermediate, and in particular, the present invention relates to a compound represented by formula IV, wherein R 1 is a hydroxyl protecting group, preferably a (C 1-10 alkyl group or aryl group) 3 silyl group, and more preferably TBDPS; and R 2 is a hydroxyl protecting group, preferably a benzyl group or(C 1-10 alkyl group or aryl group) 3 silyl group, and more preferably a benzyl group or TBS. The present invention also particularly relates to a method for preparing the compound represented by formula IV. The method has the advantages of a moderate reaction condition, simple and convenient operation and low synthesis cost, and is suitable for mass production. |