| abstract |
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof:wherein Y1 is of formula (ϰ) or formula (y):Ring Y is a 5- to 6-membered heteroaryl ring; and V 4 , V 5 , R x , x, y, and n are as defined herein. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described. |