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publicationDate 2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015200576-A1
titleOfInvention Systems and methods for controlling focused ultrasound to target release of a therapeutic agent from temperature-sensitive liposomal carriers
abstract Systems and methods are described for using focused ultrasound to promote the delivery of a temperature-sensitive liposomal carrier containing a therapeutic agent across the blood-brain barrier ("BBB"), where the temperature-sensitive liposomal carrier is then triggered to release the therapeutic agent using focused ultrasound. An advantage of the systems and methods described here is the ability to improve delivery of the therapeutic agent to a tissue-of-interest (e.g., tumor cells, such as those in a brain tumor) while minimizing the systemic dose.
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