| abstract |
The invention relates to BET-protein-inhibiting 1,4-dihydropyrido[3,4-b]pyrazinones with meta -substituted aromatic amino or ether groups of general formula (I), in which A, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and n have the meanings indicated in the description, pharmaceutical agents containing the claimed compounds, and the prophylactic and therapeutic use of said pharmaceutical agents in the case of hyperproliferative diseases, in particular in the case of tumor diseases. The invention further relates to the use of BET protein inhibitors in the case of viral infections, neurodegenerative diseases, inflammatory diseases, and atherosclerotic diseases and in male fertility control. |