| abstract |
The present invention provides peptides comprising a sequence of X- 6 X- 5 X- 4 X- 3 X- 2 X- 1 X 1 PX 3 X 4 PX 6 X 7 PGX 10 X 11 AX 13 X 14 X 15 X 16 LX 18 X 19 X 20 X 21 X 22 X 23 LX 25 X 26 YLX 29 X 30 X 31 X 32 wherein the amino acids X -6 , X -5 , X -4 , X -3 , X -2 , X -1 , X 1 X 3 , X 4 , Χ 6 , Χ 7 , Χ 10 , X 11 , X 13 , X 14 , X 15 , X 16 , X 18 , X 19 , X 20 , X 21 , X 22 , X 25 , X 26 , X 29 , X 30 , X 31 , and X 32 are as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology. |