| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f97f0fa258a008bf056ad04b7f380dda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7d7f51b30ceeb9e2e0d55b74908ec06 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2015-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f6e6691e05b51ad5930fb2174dcd28f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edd70441ca383cd12f7757b54d9ed373 |
| publicationDate |
2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015178398-A1 |
| titleOfInvention |
SURROGATE BIOMARKER FOR EVALUATING INTRACEREBRAL AMYLOID β PEPTIDE ACCUMULATION AND METHOD FOR ANALYSIS THEREOF |
| abstract |
Provided are: a biomarker for evaluating intracerebral Aβ accumulation using as the index amyloid precursor protein (APP)-derived peptide in a biologically derived sample; and a method for analysis thereof. A biological sample derived from a subject is assayed and at least one ratio selected from the group consisting of APP669-711/APP672-713(Aβ1-42); APP672-709(Aβ1-38)/APP672-713(Aβ1-42); APP674-711(Aβ3-40)/APP672-713(Aβ1-42); APP672-710(Aβ1-39)/APP672-713(Aβ1-42); APP672-711(Aβ1-40)/APP672-713(Aβ1-42); and APP672-711(OxAβ1-40)/APP672-713(Aβ1-42) is found. Assuming that the ratios in a person of normal cognitive function NC- who tests negative for intracerebral Aβ accumulation are the standard levels, if a subject ratio is higher than the corresponding standard level ratio, the amount of cerebral Aβ accumulation of a subject is determined to be higher than the amount of cerebral Aβ accumulation of a person of normal cognitive function NC-. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7105510-B6
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022030032-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7207517-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2020179224-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2020217865-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111588348-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019167830-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020261608-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022031783-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020511662-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021181999-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111588348-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7105510-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017047529-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020203878-A1 |
| priorityDate |
2014-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |