http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015177811-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a0825003d73afa252a78756ca382131 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2015-086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2405-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-94 |
| filingDate | 2015-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdf3accb091b5bc09f48a0c863cf27a9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1089a13f1c02b8ad5a777611cb2b44c6 |
| publicationDate | 2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2015177811-A2 |
| titleOfInvention | System and method for measuring permeability of drugs/toxic/ chemical compounds |
| abstract | An improved system and method for measuring the permeability of drugs/toxin chemical compounds utilizing phospholipid monolayer is disclosed. A phospholipid monolayer can be deposited on to a cellulose membrane by vertical lifting or Langmuir Schafer technique. The phospholipid monolayer or Langmuir Blodgett (LB) film can be coated on the cellulose membrane or porous support. Depositing the lipid onto porous support without the use of solvent and maintaining the lipid arrangement,packing similar to biological cell membrane is challenging. The lipid coated membrane support is attached to donor wells, which can be fabricated using Polystyrene tubes/ Poly acrylic tubes. The permeability of the drug/toxin/chemical compound can be further measured using the phospholipid monolayer by Boyden chamber approach. Such an improved method and system can be adapted for effective measurement of permeability of drugs/toxin chemical compounds through lipid layer in order to predict entry of such compounds into the blood stream. The current monolayer based system(LB- PAMPA) is solvent free, the lipid arrangement is similar to cell membrane and hence biomimetic, The system utilizes lipid monolayer which contains lipid molecules arranged in a definite order approaching packing in the cell membrane. The method can be adapted for mixture of lipids or pure lipids, the coating method is scalable and the entire system is High throughput and biomimetic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11293911-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111100789-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111100789-B |
| priorityDate | 2014-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.