http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015173393-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd43e12353298376fd7642260c1dbca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-10 |
| filingDate | 2015-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88c50da2092b2d7b71dca88d02839d1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_992fb41b44728265cb72e31dd3061ad0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b391ccfe844e45018de4418b109aa102 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d1993336eda7f160bde981da0da3978 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5e4913aefcfd104449f9ec37cce2e9e |
| publicationDate | 2015-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2015173393-A1 |
| titleOfInvention | Oxindole compounds carrying a nitrogen-bound spiro substituent and use thereof for treating vasopressin-related diseases |
| abstract | The present invention relates to novel substituted oxindole derivatives of the formula I wherein A is a ring selected from phenyl and 6-membered hetaryl containing 1 or 2 nitrogen atoms as ring members, where ring A carries one substituent R 6 and optionally one substituent R 7 ;B is a ring selected from phenyland a monocyclic or bicyclic het- eroaromatic ring containing 1, 2 or 3 heteroatoms selected from O, N and S as ring members, where ring B may carry 1, 2 or 3 substituents R 8 ;X 1 , X 2 , X 3 and X 4 , independently of each other, are selected from -CH 2 -, -O-, -S(O) c -, -NH-, -C(O)-, -CH 2 CH 2 -,-CH 2 O-, -OCH 2 -, -S(O) c CH 2 -, -CH 2 S(O)c-, CH 2 NH-,-NHCH 2 -, -CH 2 C(O)-andC(O)CH 2 -;X 5 is NH,CH 2 or O,;and wherein c, R 1 , R 2 , (R 3 )a, (R 4 )b, R 5 , R 6 , R 7 , and R 8 are as defined in the claims. The present invention also relates to pharmaceutical compositions comprising the novel substituted oxindole derivatives of the formula I, and to their use for the treatment of vasopressin-related disorders. |
| priorityDate | 2014-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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