| abstract |
The present invention provides a compound that has a strong regulatory effect for an α7 nicotinic acetylcholine receptor (α7 nAChR), and is useful as a therapeutic drug for diseases associated with cholinergicity of the central nervous system (CNS) and/or the peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine disease, diseases associated with neurodegeneration and the like. Provided is a compound of formula (I), or a pharmaceutically acceptable salt of said compound [In the formula, X-Y-Z represents N-CO-NR 4A R 4B or the like, R 1 represents an optionally substituted phenyl or the like, R 2A represents chlorine or the like, R 2B represents a hydrogen atom or the like, R 3A , R 3B , R 3C , and R 3D are the same or different and represent a hydrogen atom or the like, R 4A and R 4B are the same or different and represent an optionally substituted C 3-10 cycloalkyl or the like, and n represents 1 or 2]. |