http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015149753-A3

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filingDate 2015-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015149753-A3
titleOfInvention Physical self-organizing hydrogel system for biotechnological applications
abstract The invention relates to a physical self-organizing hydrogel system for biotechnological applications composed of a non-covalent network on the basis of a protein-ligand interaction, comprising a tetrameric protein as a protein and biotin or one of the derivatives thereof as a ligand, wherein biotin or one of the derivatives thereof is covalently conjugated to an end of a polymer chain of a linear or multi-arm synthetic polymer or of a single- or double-strand oligonucleotide and wherein the solid content in relation to the entire hydrogel is at least 3% and the conjugates are cross-linked by the tetrameric protein. In the hydrogel system, there is a mixture ratio as a molar equivalent ratio between the protein and the number of terminal biotinylated ends of the polymer chains in the biotin-polymer conjugate of 1:2 to 1:8. The hydrogel formation occurs with controlled kinetics on the basis of a protein-ligand interaction. The hydrogel system can be used for the cultivation and encapsulation of cells.
priorityDate 2014-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 26.