| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7bce595c861dba361078ba893e4713be |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-974
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6432
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-6439 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-582
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-587
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6428
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-56 |
| filingDate |
2015-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d0085932c70956ecb946b54804e1f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11884d1298d19ec06dfb7f682e1e0658
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_956cc61d01bd0724e4d049dff19a0b2e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f773618476b6764b98ee84c4e9234251
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_725c7bd4f43742029ba24d233db8386b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc79934522daae22d895aa1664133169 |
| publicationDate |
2015-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015148622-A1 |
| titleOfInvention |
Nanosensor for assessing thrombin inhibitors |
| abstract |
Constructs and monitoring systems to assess the level of molecules that bind to thrombin (e.g. thrombin regulators and inhibitors) are provided. The constructs are nanosensors comprising i) a thrombin molecule to which is bound a reporter ligand comprising a fluorescent label, ii) a fluorescence-quenching metal nanoparticle, and, optionally iii) a fluorescence-quenching dye molecule attached to one or both of the nanoparticle and the thrombin molecule. The binding of a thrombin regulator or inhibitor to the thrombin molecule displaces the reporter ligand, and the signal from the fluorescent label increases. The increase is proportional to the concentration of thrombin-binding molecule in the sample. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3519583-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11604193-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018064383-A1 |
| priorityDate |
2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |