http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015144854-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_80684a2ac1cbb90a41323772be644fb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_460f372bf0a1961f686e03af8e23c7a3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2015-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_712b06d43d363abc112f12fd9abc11cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a7b34ec070477db57bdaa5be0726b3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74cc14ad5c737d3f958290a3c14ff150 |
| publicationDate | 2015-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2015144854-A1 |
| titleOfInvention | Method for predicting patient outcome and therapy response in metastatic colorectal cancer |
| abstract | Method for predicting patient outcome and therapy response in metastatic colorectal cancer. The method is based on the detection of the expression level of a panel of genes expressed in epithelial CTCs (GAPDH, VIL1, TIMP1, CLU, LOXL3, ZEB and TLN1), preferably normalized to CD45 or another gene not expressed in CTCs, and the comparison of the evolution of said levels in blood samples taken at different time points from mCRC patients undergoing therapy. The samples are classified in accordance with the expression levels of at least one of said genes or, preferably, a combination of six (GAPDH, VIL1, TIMP1, CLU, LOXL3, ZEB) or seven genes, as high- or low-CTC, the change to low or maintenance of the classification as low indicating therapy effectiveness. The method is easy to perform and can be carried out early during therapy course, allowing early decisions about continuation of therapy administration to non responding patients. |
| priorityDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.