| abstract |
Disclosed herein are methods for inhibiting the growth or survival of cholesterol auxotrophic cancer cells, for example, by limiting the availability of extracellular cholesterol in the cholesterol auxotrophic cancer cells. In some aspects, the disclosure provides a method of inhibiting growth or survival of a cancer cell that is cholesterol auxotrophic due to inadequate squalene epoxidase (SQLE) expression, the method comprising limiting the availability of extracellular cholesterol in a cancer cell that is cholesterol auxotrophic due to inadequate SQLE expression, thereby inhibiting growth or survival of the cancer cell that is cholesterol auxotrophic due to inadequate SQLE expression. |