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publicationDate 2015-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015135474-A1
titleOfInvention Pentacyclic triterpene compound and use thereof in preparation of drug for treating alzheimer's disease
abstract Disclosed are a pentacyclic triterpene compound represented by general formula (I) and pharmaceutical compositions containing the compound. Also disclosed is use of the compound in preparation of a PS1/BACE1 interaction inhibitor, and uses thereof in preparation of drugs for treating Alzheimer's disease. Disclosed for the first time is that a pentacyclic triterpene compound represented by general formula (I) can be used as a PS1/BACE1 inhibitor, having activity of inhibiting PS1/BACE1 interaction, and can reduce generation of Aβ and be used in preparation of drugs for treating Alzheimer's disease.
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