| abstract |
[Problem] In nucleic acid medicine that expresses nucleic acid functions by administering nucleic acid into the blood, there is a need for ensuring stability of the nucleic acid medicine and a need for a composition for nucleic acid delivery that has a high intracellular introduction rate and is capable of efficiently expressing functions of the nucleic acid medicine. In particular, there is a need for a composition for nucleic acid delivery that can be applied to a short-chain nucleic acid medicine such as siRNA. [Solution] Provided is a composition for nucleic acid delivery including: a bifunctional polymer (a) into which a cationic functional group and a hydrocarbon group are introduced; a block copolymer (b) in which a polyethylene glycol segment and a hydrophobic polymer segment are joined; and one type or more of a fat-soluble additive (c) selected from the group consisting of a vitamin A derivative, vitamin D derivative, vitamin E derivative, vitamin K derivative, and cholesterol derivative. |