| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42a59c5faed1d0699d86edc5a2eee671 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-11013
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-56
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-48 |
| filingDate |
2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecf1491e6fc89f2218a4f23058e8f5aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7fe97c874c7354c6183f563bd8542b2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f48d809ddffcaa87d74a63897b122518 |
| publicationDate |
2015-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015132004-A1 |
| titleOfInvention |
Novel recombinant clostridial neurotoxins with increased duration of effect |
| abstract |
This invention relates to novel recombinant clostridial neurotoxins exhibiting increased duration of effect and to methods for the manufacture of such recombinant clostridial neurotoxins. These novel recombinant clostridial neurotoxins comprise a random coil domain, and the methods comprise the steps of inserting a nucleic acid sequence coding for a random coil domain into a nucleic acid sequence coding for a parental clostridial neurotoxin and expression of the recombinant nucleic acid sequence comprising the random coil domain-coding sequence in a host cell. The invention further relates to novel recombinant single-chain precursor clostridial neurotoxins used in such methods, nucleic acid sequences encoding such recombinant single-chain precursor clostridial neurotoxins, and pharmaceutical compositions comprising the recombinant clostridial neurotoxin with increased duration of effect. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019081022-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018233813-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017125487-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020354706-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11548931-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3290437-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3333179-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11078472-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017063743-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10688162-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10603353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018132423-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11357821-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11155802-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018169182-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019007509-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3710483-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3919623-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019101308-A1 |
| priorityDate |
2014-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |