http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015131259-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f3c4138dd341b8263ee44633c9b35187 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-2242 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 |
| filingDate | 2014-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da00d08c482b2d9a70a6b3d3589969d4 |
| publicationDate | 2015-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2015131259-A1 |
| titleOfInvention | Method of treating pulmonary hypertension by administration of natriuretic peptide receptor c activators |
| abstract | The present invention is based upon the observation that a loss of function or mutations of gene encoding the C-type natriuretic peptide receptor (NPR-C) or the inhibition of NPR-C pathway may lead to the development of pulmonary arterial hypertension (PAH). Accordingly, the invention proposes a method of using synthetic analogs of NPR-C pathway, specifically synthetic C-type atrial natriuretic factor or intermediates for or modulators of NPR-C pathway as anti-pulmonary vasculopathy agents. Activators to NPR-C pathway, as well as polynucleotides encoding NPR-C or positively regulating the expression of NPR-C, are disclosed to treat or prevent vasculopathy, including but not limited to PAH and other types of pulmonary hypertension, peripheral vascular disease, critical limb ischemia, coronary artery disease, and diabetic vasculopathy. The invention also proposes methods of diagnosis, prediction of treatment response, and screening for alleles of the NPR-C gene that may cause the development of PAH and associated disorders. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10087144-B2 |
| priorityDate | 2014-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.