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filingDate 2015-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015125147-A1
titleOfInvention Anionic polyplexes for use in the delivery of nucleic acids
abstract The present invention provides an anionic polyplex formed from a nucleic acid and an anionic polymer and further comprising a cation, which can be in the form of a nanoparticle or a microparticle and compositions comprising the anionic polyplex. The present invention further provides uses of the anionic polyplex such as delivery of the nucleic acid into cells and methods of treating a disease, disorder or condition selected from cancer or metabolic, neurodegenerative, cardiovascular, infectious or inflammatory diseases or disorders. The present invention also provides complexes comprising a divalent cation and a nucleic acid lacking an anionic polymer in the form of nanoparticles that is capable of forming a colloidal suspension, and methods for its production.
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