http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015123439-A2

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filingDate 2015-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015123439-A2
titleOfInvention Methods of promoting neuroblast differentiation and treating neuroblastoma and of providing a prognosis for subjects with neuroblastoma
abstract Methods of promoting neuroblast differentiation in subjects with neuroblastoma by administering an. agent to a subject with neuroblastoma are provided herein. The agent may be a heparin -sulfate proteoglycan co-receptor, heparin sulfate or a heparin analog. Promotion of neuroblast differentiation, may suppress neuroblast growth and treat neuroblastoma... Methods of determining a prognosis for a subject with neuroblastoma are also provided. The methods include measuring the level of at least one marker selected from FGF2, FGFR1, ID1, TĪ²RIII, SDC3, SDC4, GPC3 and GPC1 in a sample from the subject and comparing the level in the subject to a reference level. If the levels of any of the markers are higher than the reference level the subject has a good prognosis. If the levels are lower than the reference level, the prognosis is poor.
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priorityDate 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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