| abstract |
The invention relates to bromodomain protein-inhibiting, in particular BET protein-inhibiting, and preferably BRD4-inhibiting 3H-2,3-benzodiazepines of general formula (I), in which R 1a , R 1b , R 1c , R 2 , R 3 , R 4 and R 5 have the meanings specified in the description, to pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use of said pharmaceutical agents in hyperproliferative diseases, in particular tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasias, atherosclerotic diseases, sepsis, autoimmune diseases, vascular diseases, viral infections, neurodegenerative diseases, inflammatory diseases, atherosclerotic diseases, and in male fertility control. |