| abstract |
This peptide/β-1,3-glucan complex contains β-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded via a covalent bond to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with β-1,3-glucan, forming a complex having a triple helix structure comprising a single molecular chain of the polynucleotide or derivative thereof and a double molecular chain of the β-1,3-glucan. Alternately, the side chain of the β-1,3-glucan and the antigenic peptide are bonded via a covalent bond created through either a cycloaddition reaction between an alkyne and an azide derivative, or a reaction between a maleimide group or a vinyl sulfone group and a thiol group. |