| abstract |
A method for determining the systems biology state of an animal, which comprises determining levels of small molecules covalently bound to macromolecules (CBSM) in samples from that animal, and using said levels to determine the risk, diagnostic state and progression of disease in that animal. A therapy development method for determining the structure of covalently bound molecules and their precursors and modifying the sources and mechanisms causing such binding to reduce disease risk and progression. |