| abstract |
The present invention relates to pH probes of formula I: wherein: W represents O, NH, N(alkyl), Si(alkyl) 2 , CH 2 , CH(alkyl), C(alkyl) 2 ; preferably W represents O; X 1 and X 1' represent both H, both Me or both -CH 2 -S0 3 H; X 2 and X 2' represent both H or both Me; X 3 and X 3' represent both H or both Me; X 4 and X 4' represent both H or both Me; X 5 and X 5' represent both H or both Me; X 6 and X 6' represent both H or both Me; Z 1 , Z 2 and Z 3 , represent each independently H, electron withdrawing group or electron donating group, L represents a single bound or a linker, Y represents a reactive group, or a bioactive group. The invention also relates to a process for manufacturing said compounds. The invention further relates to the use of the compounds of the invention as pH probes. |