| abstract |
Provided in the present invention are an acyclic nucleoside phosphonate derivative and a preparation method and use thereof in medical science, and the acyclic nucleoside phosphonate derivative is a compound as shown by general formula (I), a stereoisomer or a pharmaceutically acceptable salt thereof: R 1 is H or methyl; R 2 is H, C 1-10 alkyl, -(CH 2 -CH 2 -O) n -H or -(CH 2 -CH 2 -O) n -C 1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R 2a s; R 3 is C 1-10 alkyl, -(CH 2 -CH 2 -O) n -H or -(CH 2 -CH 2 -O) n -C 1-10 alkyl, wherein the alkyl is optionally further substituted by 0 to 5 R 3a s; each of R 2a and R 3a are independently H, F, Cl, Br, I, hydroxyl, sulfydryl, amino, cyano, carboxyl, C 1-4 alkyl or C 3-6 cycloalkyl; and n is 1-10. |