http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015089080-A2

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filingDate 2014-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00f7e1d2630f49dfd31853fe6fa6702b
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publicationDate 2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015089080-A2
titleOfInvention Polyclonal mixtures of antibodies, and methods of making and using them
abstract A method of broadening epitopic coverage of an antigen of interest, wherein a first sample of the antigen of interest is contacted with a first plurality of host cells collectively expressing a first library of antibodies. Host cells expressing antibodies that bind to the antigen are then collected from among the first plurality of host cells, and a composition is prepared comprising a polyclonal mixture of antibodies expressed by these host cells. A second sample of the antigen of interest is then contacted with an aliquot of the prepared composition and a second plurality of host cells collectively expressing a second library of antibodies. Host cells expressing antibodies that bind to the second sample of the antigen are then collected from among the second plurality of host cells.
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017109721-A1
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