| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d5d546aa6cbfb52c137af7cafc36bf4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2300-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-119
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-727
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2506-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0621
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3641
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-44 |
| filingDate |
2014-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f229fac0e8c8d4f0eaaa6d15500dec0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c79cbd48393a2a3b9df30d3e452f855e |
| publicationDate |
2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015087614-A1 |
| titleOfInvention |
Method for manufacturing ciliary marginal zone-like structure |
| abstract |
The present invention provides a method for manufacturing a cell aggregate containing a ciliary marginal zone-like structure, the method comprising a step for culturing a retinal tissue-containing cell aggregate, wherein the percentage of Chx10-positive cells present in the retinal tissue is 20% to 100%, in a serum-free medium or serum medium containing a Wnt signal pathway-affecting substance and a FGF signal pathway-inhibiting substance only in the period until cells expressing RPE65 gene appear, and then the obtained "cell aggregates in which RPE65 gene-expressing cells have not appeared" are cultured in a serum-free medium or serum medium that does not contain a Wnt signal pathway-affecting substance. The manufacturing method according to the present invention makes it possible to manufacture ciliary marginal zone-like structures with high efficiency. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11241460-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019017492-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11724005-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3095857-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019054515-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019054514-A1 |
| priorityDate |
2013-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |