| abstract |
The present disclosure provides antagonizing antibodies that specifically bind sclerostin. The disclosure further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The disclosure further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of bone related disorders, including, for example, multiple myeloma, osteoporosis, osteopenia, Paget's Disease, bone fracture, or bone loss. Methods of increasing bone formation, bone mass, bone volume, bone mineralization, bone quality, bone strength, or bone density as well as methods of inducing canonical Wnt signaling activity and methods of preventing or reducing tumor burden, methods of inhibiting or preventing tumor growth or progression, methods of inhibiting metastasis of cancer cells or tumors or delaying tumor growth or progression are also provided. |