| abstract |
The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the derivative, X 1 , X 2 , X 3 , and X 4 are linking groups, F 1 , F 2 , F 3 , and F 4 are end groups, the end groups may be the same or may also be different, and are selected from: oxhydryl, carboxyl, ester groups, amine groups, alkynyl or the like, at least one of the end groups is alkynyl, and PEG is the same or different-(CH 2 CH 2 O) m -, wherein m is an integer ranging from 3 to 250, and l is an integer greater than or equal to 1. The multi-arm polyethylene glycol has multiple branches, may be loaded with multiple active end groups, and meanwhile may further be loaded with multiple different active end groups, so that the obtained multi-arm polyethylene glycol derivative has a stronger application flexibility and a larger application range, and has a good application prospect in aspects such as organic synthesis, medicine synthesis and medical devices. |